CONTROL OF A GENE INDUCED BY OXIDIZED LIPIDS IN HUMAN ARTERY WALL CELLS

摘要

A kit for evaluating the risk of atherosclerosis in a mammal, said kit comprising a container containing one or more oxidised or non-oxidized phospholipids, and instructional materials describing the following assay for evaluating the risk of atherosclerosis in a mammal: (A) contacting a high density lipoprotein (HDL) comprised in a biological sample from said mammal with an oxidised phospholipid; and measuring a change in the amount of oxidised or non-oxidised phospholipid wherein the absence of change in the amount of oxidised phospholipid indicates the mammal is at risk of atherosclerosis or (B) contacting a high density lipoprotein (HDL) comprised in a biological sample from said mammal with a phospholipid; subjecting the phospholipid to oxidising conditions; and measuring a change in the amount of oxidised or non-oxidised phospholipid wherein a change in the amount of oxidised or non-oxidised phospholipid indicates the mammal is at risk for atherosclerosis