METHOD OF DETECTING INTERACTION BETWEEN POLYPEPTIDE AND RECEPTOR, METHOD OF SCREENING LIGAND OR LIGAND VARIANT BY THE DETECTION METHOD AND METHOD OF DIAGNOSIS UTILIZING THE DETECTION METHOD

摘要

A method of rapidly and conveniently detecting the interaction between polypeptide and receptor. There is provided a method of detecting the interaction between polypeptide and receptor, comprising immobilizing a polypeptide on a carrier whose surface layer has a functional group and a carbonaceous substance; reacting the same with a receptor derivative that contains an extracellular domain of membrane receptor on a cell surface but does not contain any region indispensable for membrane binding; and detecting any interaction between the immobilized polypeptide and the receptor derivative.