TWO-DIMENSIONALLY QUANTIFIED IMAGE METHOD FOR DISTINGUISHING AND QUANTIFYING OVERGROWING TISSUE OR THE LIKE

摘要

The present invention provides a rapid screening method for new drug candidates by providing an early visual indication of pharmacological effects [growth suppression or inhibition] in vivo of drugs administered to animals harboring an excessive growth of tissues or cells, such as malignant tumors, and the like, and a rapid method for establishing an appropriate use of therapeutic drugs.;The present invention is a two-dimensional quantitative imaging method for identifying and quantifying abnormally growing tissues or cells from normally grown tissue or cells by a two-dimensional image, preferably by a two-dimensional image analysis of a macro-autoradiograph, based on the marker [2-14C] thymidine or [1,3-N] fluorescent thymidine. Also, the present invention is a two-dimensional quantitative imaging method for simultaneously acquiring two-dimensional quantitative images of a radioactive nuclide and said thymidine. Further, the present invention, based on the aforementioned two-dimensional quantitative imaging method, is a rapid screening method for new drug candidates; a rapid method for establishing an appropriate use of therapeutic drugs; a method for determining the optimum dose of high-energy particles; a method for determining the ratio of the moiety retaining chemical stability of a therapeutic drug; a method for determining the lethal effect of high-energy particles; a method for determining the efficacy of a drug exhibiting tissue-specific efficacy; and a method for establishing an applicable dose of 90Y.