USE OF ORGANIC ANION TRANSPORTER B IN SCREENS FOR CANDIDATE SUBSTRATES FOR CROSSING THE BLOOD BRAIN BARRIER

摘要

OATPB is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the OATPB transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in screening for therapeutic, cytotoxic or imaging compounds used in the treatment or diagnosis of neurological diseases.