DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN METABOTROPIC GLUTAMATE RECEPTOR 2 (MGLUR2)

摘要

The invention provides a human mGluR2 which is associated with the cardiovascular diseases, cancer, hematological diseases, respiratory diseases, inflammation, metabolic diseases, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, hematological diseases, respiratory diseases, inflammation, metabolic diseases, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of mGluR2 as well as pharmaceutical compositions comprising such compounds.