USE OF CROSS-LINKED, COVALENTLY BOUND UROKINASE PLASMINOGEN ACTIVATOR (SCUPA)-UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR (SUPAR) COMPLEX AS A FIBRINOLYTIC AGENT

摘要

The present invention relates to the cross-linked scuPA/suPAR complex and/or tcuPA/suPAR cross-linked complex, the process of preparation of the covalently bound single compound having fibrinolytic activity and use of the cross-linked scuPA/suPAR or tcuPA/suPAR complex in the prevention and/or treatment of thrombolytic disorders. The invention further relates to combination compositions and/or therapy regimens, comprising the cross-linked scuPA/suPAR complex or tcuPA/suPAR and one or more currently used plasminogen activators to achieve improved therapeutic efficacy and/or reduce side effects.