首页>
外国专利>
AFFINITY PURIFIED HEPARIN/HEPARAN SULFATE FOR CONTROLLING THE BIOLOGICAL ACTIVITY OF THE FGF RECEPTOR
AFFINITY PURIFIED HEPARIN/HEPARAN SULFATE FOR CONTROLLING THE BIOLOGICAL ACTIVITY OF THE FGF RECEPTOR
展开▼
机译:亲和纯化的肝素/肝素硫酸盐可控制FGF受体的生物活性
展开▼
页面导航
摘要
著录项
相似文献
摘要
Methods and compositions for modulating the activity of a FGF receptor in a mammal are disclosed. The methods and compositions utilize substantially purified heparin/heparan sulfate oligosaccharides (HS) that have high affinity for FGF7. HS that has high affinity for FGF7 has increased activity for promoting the formation of a ternary FGF/HS/FGFR complex. According to one embodiment of the invention, substantially purified HS is an octasaccharide having 7 or 8 sulfates and having predominant disaccharide composition of ΔHexA2SG1cN6S and a tri-sulfated disaccharide. Alternatively, the substantially purified HS is a longer oligosaccharide that contains an octasaccharide structural motif having 7 or 8 sulfates and having predominant disaccharide composition of ΔHexA2SG1cN6S and a tri-sulfated disaccharide.
展开▼