首页> 外国专利> NOVEL ABIETANE DITERPENOID COMPOUND, AND COMPOSITION COMPRISING EXTRACT OF TORREYA NUCIFERA, OR ABIETANE DITERPENOID COMPOUNDS OR TERPENOID COMPOUNDS ISOLATED FROM THEM FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE

NOVEL ABIETANE DITERPENOID COMPOUND, AND COMPOSITION COMPRISING EXTRACT OF TORREYA NUCIFERA, OR ABIETANE DITERPENOID COMPOUNDS OR TERPENOID COMPOUNDS ISOLATED FROM THEM FOR PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE

机译：新颖的二庚烷二萜化合物，以及由托雷娅核仁提取物组成的组合物，或从中分离出来的用于预防和治疗心血管疾病的二庚烷二萜化合物或萜类化合物

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摘要

The present invention relates to a composition for the prevention and the treatment of cardiovascular disease containing extracts of T. nucifera or abietane diterpenoid compound or terpenoid compound isolated from the same as an effective ingredient. T. nucifera extracts or abietane diterpenoid compound or terpenoid compound isolated from the same of the present invention not only shows excellent anti-oxidative activity to LDL but also effectively inhibits ACAT activity. Further, T. nucifera extracts of the present invention reduce blood LDL cholesterol and total cholesterol. Therefore, the composition of the present invention can be effectively used for the prevention and the treatment of cardiovascular diseases including hyperlipidemia and atherosclerosis caused by the LDL oxidation and the synthesis and accumulation of cholesteryl ester.

机译：本发明涉及用于预防和治疗心血管疾病的组合物，其包含从中分离出的紫杉（T.nucifera）或山茱a烷二萜类化合物或萜类化合物的提取物作为有效成分。从本发明提取的核仁提取物或山茱a二萜类化合物或萜类化合物不仅显示出对LDL的优异的抗氧化活性，而且还有效地抑制了ACAT活性。此外，本发明的丁香提取物降低血液中的LDL胆固醇和总胆固醇。因此，本发明的组合物可以有效地用于预防和治疗由LDL氧化和胆固醇酯的合成和积聚引起的心血管疾病，包括高脂血症和动脉粥样硬化。

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公开/公告号WO2005084141A2

专利类型
公开/公告日2005-09-15

原文格式PDF
申请/专利权人 KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY;MOON OG-SUNG;SON JUN-SEOCK;JEONG TAE-SOOK;LEE WOO-SONG;KIM HYOUNG-CHIN;CHOI YANG-KYU;KIM JU-RYOUNG;AN SO-JIN;IM KYOUNG-RAN;JANG KI-CHANG;
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申请/专利号WO2005KR00472
发明设计人 MOON OG-SUNG;SON JUN-SEOCK;JEONG TAE-SOOK;LEE WOO-SONG;KIM HYOUNG-CHIN;CHOI YANG-KYU;KIM JU-RYOUNG;AN SO-JIN;IM KYOUNG-RAN;JANG KI-CHANG;
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申请日2005-02-22
分类号C07C39/17;
国家 WO
入库时间 2022-08-21 22:08:46

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7. 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