NON-GLYCOSYLATED/NON-GLYCOSIDIC/NON-PEPTIDIC SMALL MOLECULE PSGL-1 MIMETICS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

摘要

Pharmaceutical compositions comprising at least one compound of the formulas (Ia) or (Ib) and a pharmaceutically acceptable carrier which is useful in a medicine, formula (Ia) and formula (Ib), wherein the symbols, indices and substituents have the following meaning R1=H, CN, NO2, CF3, F, Cl, Br, I, CH3 R2=H, CN, NO2, CF3, F, Cl, Br, I, CH3, Et, n-Pr, i-Pr, n-Bu, t-Bu, phenyl, thienyl, furyl, thiazolyl and either R1 or R2 must be H R3=H, CN, NO2, CF3, F, Cl, Br, I, CH3, Et, n-Pr, i-Pr, n-Bu, t-Bu, phenyl, thienyl, furyl, thiazolyl then X is e.g., formula (II), or, formula (III), with R4 being H, CH3, CH2CH3 or, formula (IV), or, formula (V), and Y being, formula (VI), or, formula (VII), or the pharmaceutically acceptable salts, esters or amides and prodrugs of the above identified compounds of formula (Ia) or (Ib). The compounds are applied to modulate the in-vitro and in-vivo binding processes mediated by E-, P- or L-selectin binding.