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DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN COUPLED RECEPTOR 58 (GPR58)
DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN COUPLED RECEPTOR 58 (GPR58)
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机译:与G蛋白偶联受体58(GPR58)相关的疾病的诊断和治疗
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摘要
The invention provides a human GPR58 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, neurological disorders, urological disorders, respiratory diseases, cancer disorders and inflammatory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, neurological disorders, urological disorders, respiratory diseases, cancer disorders and inflammatory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR58 as well as pharmaceutical compositions comprising such compounds.
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