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DIAGNOSTIC AND THERAPEUTIC USE OF RAS-GTPASE-ACTIVATING SH3-DOMAIN-BINDING PROTEIN 2 (G3BP2) FOR NEURODEGENERATIVE DISEASES
DIAGNOSTIC AND THERAPEUTIC USE OF RAS-GTPASE-ACTIVATING SH3-DOMAIN-BINDING PROTEIN 2 (G3BP2) FOR NEURODEGENERATIVE DISEASES
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机译:RAS-GTPase激活SH3域结合蛋白2(G3BP2)在神经退行性疾病中的诊断和治疗应用
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摘要
The present invention discloses the differential expression of the G3BP2 gene in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using the G3BP2 gene and its corresponding gene products. A method of screening for modulating agents of neuro-degenerative diseases is also disclosed.
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