STRUCTURE OF A COMPLEX OF RETINOBLASTOMA PROTEIN BOUND TO E2F, AND USES THEREOF

摘要

The present invention provides the crystal structure of pRb/E2FSUB(409-426) /SUBas well as uses of the structure in identifying agents which modulate the binding between pRb and E2F and/or a pRb/E2FSUB(409-426) /SUBcomplex, and thus are useful as pharmaceutical agents in the prevention or treatment of proliferative diseases.