METHODS OF TREATMENT OF FEEDING DISORDERS OR DISORDERS OF GLUCOSE UPTAKE AND FOR MODIFYING METABOLISM AND IDENTIFYING THERAPEUTIC REAGENTS THEREFOR

摘要

The present invention provides several assay formats for determining the effect of compounds on one or more metabolism-associated phenotypes in a cell, tissue or animal. The assay formats are based upon the finding that the proto-oncogene Cbl is involved in modulating basal glucose uptake, metabolic rate, adipogenesis, muscle thermogenesis, mitochondrial structure and function, the ratio of lean muscle mass to body fat and feeding behavior.