SUSTANINED RELEASE PREPARATION OF PRACTICALLY WATER-INSOLUBLE DRUG TO RELEASE ACTIVE INGREDIENTS UNIFORMLY WITHIN 24 HOURS AFTER ORAL ADMINISTRATION

摘要

PURPOSE: Provided is a sustanined release preparation of practically water-insoluble drug which releases active ingredients uniformly within 24 hours after oral administration and maintains blood drug concentration regular. Therefore, the preparation displays excellent pharmacological efficacy. CONSTITUTION: The sustanined release preparation of practically water-insoluble drug is characteristically composed of a matrix layer which contains 25-55 wt.% of matrix agent, 15-45 wt.% of channeling agent, 10-45 wt.% of osmotic agent and 10-30 wt.% of solubilizing agent, and a coating layer coated on the outer surface of the matrix layer.