HUMAN PROTOONCOGENE HLC-3 USEFUL FOR DIAGNOSIS OF VARIOUS CANCERS, PROTEIN ENCODED THEREBY, METHOD FOR PRODUCING THE PROTEIN, AND DIAGNOSTIC KIT OF CANCER COMPRISING THE SAME

摘要

PURPOSE: A human protooncogene HLC-3 and a protein encoded thereby are provided. The gene is useful for diagnosis of various cancers, production of transgenic animals, and anticancer gene therapy. CONSTITUTION: The human protooncogene HLC-3 has the nucleotide sequence set forth in SEQ ID NO:1 or a portion thereof(590th to 2062th nucleotides). The protein encoded by the human protooncogene HLC-3 of SEQ ID NO:1 has the amino acid sequence set forth in SEQ ID NO:2. The method for producing the protein of SEQ ID NO:2 comprises the steps of: constructing a vector containing the human protooncogene HLC-3 of SEQ ID NO:1; transforming a microorganism with the vector containing the human protooncogene HLC-3 of SEQ ID NO:1 to produce a transformed microorganism Escherichia coli DH5/HLC-3/pCEV-LAC(KCTC 10479BP); and culturing the transformed microorganism Escherichia coli DH5/HLC-3/pCEV-LAC(KCTC 10479BP). The diagnostic kit of cancer comprises the human protooncogene HLC-3 of SEQ ID NO:1 or a protein of SEQ ID NO:2.