PURPOSE: An analysis method of macrophage reaction gene by Bacillus anthracis lethal toxin is provided, which macrophage reaction gene is useful as a biomarker, so that the presence of Bacillus anthracis lethal toxin can be easily detected by using the biomarker. CONSTITUTION: The analysis method of macrophage reaction gene by Bacillus anthracis lethal toxin comprises the steps of: treating genes with Bacillus anthracis lethal toxin; measuring and comparing the expressions of the genes treated with and without the Bacillus anthracis lethal toxin in macrophage; and selecting genes of which expression in macrophage is significantly changed by the Bacillus anthracis lethal toxin, wherein the genes of which expression is significantly changed by the Bacillus anthracis lethal toxin are RPL10A, ARBP, RPL30, RPS3, RPL3, RPS16 and MPRS17.
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