SOLID DISPERSION OF TACROLIMUS WHICH CONTAINS AMORPHOUS PHASE OF TACROLIMUS AND CARRIER THEREOF AND MANUFACTURING PROCESS THEREOF

摘要

PURPOSE: Provided is a solid dispersion carrier of tacrolimus which contains amorphous phase of tacrolimus and its carrier. And provided are a manufacturing process thereof and a preparation containing the same. Therefore, the solid dispersion dissolves the tacrolimus rapidly to increase its oral absorption and bioavailability. CONSTITUTION: The solid dispersion of tacrolimus is characterized by containing, in a weight ratio of 1:0.1-1:100, amorphous phase of tacrolimus as a drug and surfactant having an HLB value of 7 or more, and solid phase at room temperature, as a carrier. The surfactant is selected from sodium lauryl sulfates(HLB 40), poloxamers(HLB 7) or sucrose fatty acid ester(HLB 7-18).