首页> 外国专利> NUCLEOTIDE SEQUENCES THAT CODE FOR TORSIN GENES, TORSIN PROTEINS, AND METHODS OF USING THE SAME TO TREAT PROTEIN-AGGREGATION

NUCLEOTIDE SEQUENCES THAT CODE FOR TORSIN GENES, TORSIN PROTEINS, AND METHODS OF USING THE SAME TO TREAT PROTEIN-AGGREGATION

机译：编码Torsin基因，Torsin蛋白的核苷酸序列，以及使用相同的方法处理蛋白聚集的方法

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摘要

The present invention comprises a polynucleotide sequence and a portion thereof corresponding to a polypeptide sequence and tor-1, tor-2 coding for a part thereof, ooc-5,DYT1, and DYT2 gene pictures of varying degrees of cytosine (torsin) activity of for the polynucleotide and a polynucleotide encoding a polypeptide sequence that code for polypeptides having varying degrees of TOR-1, TOR2, OOC-5, TOR-a, and TOR-B activity, to a method for screening and amplification. In addition, the present invention provides a method for treating a disease caused by a method of reducing protein aggregation, protein aggregation, protein-to screen an effective therapeutic agent for diseases caused by the method for screening an effective product to reduce aggregation, protein aggregation It relates to a method, and tor-1, tor-2, ooc-5, DYT1, and DYT2 polynucleotide sequence and / or a medicament, therapeutic agent, and a kit comprising a polypeptide having an activity corresponding to cytosine gene.

机译：本发明包括多核苷酸序列及其对应于多肽序列的部分，以及编码其一部分， ooc-5， tor-1，tor-2 > DYT1，和 DYT2 基因图片，显示了该多核苷酸和编码多肽序列的多核苷酸的胞嘧啶（torsin）活性程度不同，该多肽序列编码具有不同TOR-1程度的多肽， TOR2，OOC-5，TOR-a和TOR-B的活性，用于筛选和扩增的方法。另外，本发明提供了一种用于治疗由减少蛋白质聚集，蛋白质聚集，蛋白质的方法引起的疾病的方法，以筛选由用于减少聚集，蛋白质聚集的有效产品的方法引起的疾病的治疗剂本发明涉及一种方法，以及 tor-1，tor-2， ooc-5，DYT1和 DYT2 多核苷酸序列和/或药物，治疗剂和药物。试剂盒，其包含具有与胞嘧啶基因相对应的活性的多肽。 展开▼

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公开/公告号KR20050016634A

专利类型

公开/公告日2005-02-21

原文格式PDF

申请/专利权人 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 알라바마;
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申请/专利号KR20047021061

发明设计人 컬드웰가이에이;컬드웰킴에이.;
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申请日2004-12-24

分类号C12N15/12;C12Q1/68;

国家 KR

入库时间 2022-08-21 22:05:52

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