OLIGONUCLEOTIDE FOR ACTIVATING CYTOMEGALOVIRUS(CMV) IE ENHANCER/PROMOTER ACTIVITY HAVING PROBLEMS SUCH AS DIFFICULTY OF IN VIVO CMV PROMOTER ACTIVATION AND CMV INACTIVATION BY INTERFERON AND ACTIVATION METHOD THEREOF

摘要

PURPOSE: An oligonucleotide for activating Cytomegalovirus(CMV) IE enhancer/promoter activity and an activation method thereof are provided, thereby resolving problems such as difficulty of in vivo CMV promoter activation and CMV inactivation by interferon when the CMV promoter is applied to gene therapy. CONSTITUTION: The oligonucleotide for activating Cytomegalovirus(CMV) IE(immediate early) enhancer/promoter activity comprises a CpG sequence, wherein the CpG-oligonucleotide has the nucleotide sequence selected from SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3. The method for activating Cytomegalovirus(CMV) IE enhancer/promoter activity comprises treating Cytomegalovirus(CMV) IE enhancer/promoter with 0.1 to 10 microM of CpG-oligonucleotide for 2 to 24 hours.