PROCESS FOR PREPARING 2-PYRROLIDONE DERIVATIVES WITH ONE-SPOT REACTION UNDER MILD REACTION CONDITION

摘要

PURPOSE: A process for preparing 2-pyrrolidone derivatives is provided, thereby simplifying the process into one-pot reaction, and carrying out the process under mild reaction condition. CONSTITUTION: The process for preparing 2-pyrrolidone derivatives comprises the steps of: reacting 4-amino-3-hydroxybutyric acid or alkyl ester salt thereof with haloacetamide in the presence of organic base in solvent to prepare an intermediate compound; and cyclization of the intermediate compound, wherein R is hydrogen or alkyl; the solvent is selected from dichloromethane, tetrahydrofuran, chloroform, ethylacetate, N,N-dimethylformamide, dimethylsulfoxide and a mixture thereof; the organic base is selected from triethylamine, tributylamine, 1,8-diazabicyclo£5.4.0|undec-7-ene, 1,5-diazabicyclo£4.3.0|non-5-ene and a mixture thereof; and the 2-pyrrolidone derivatives are nootropic agents that enhances reduction of memory, attention or concentration, disorder of language and action, emotional anxiety and enthusiasm deficiency.