ANTIMALARIAL COMPOSITION COMPRISING SPIRO AND DISPIRO 1,2,4-TRIOXOLANE HAVING IMPROVED PHARMACOKINETICAL PROPERTIES INCLUDING NON-NEUROTOXICITY, AND IMPROVED STABILITY AND ORAL ABSORPTION

摘要

PURPOSE: An antimalarial composition comprising spiro and dispiro 1,2,4-trioxolane is provided, which compound has improved pharmacokinetical properties including non-neurotoxicity, and improved stability and oral absorption, so that they are useful for prevention and treatment of malaria. CONSTITUTION: The antimalarial composition comprises spiro and dispiro 1,2,4-trioxolane selected from the group consisting of OZ271, OZ272, OZ273, OZ274, OZ275, OZ276, OZ277, OZ278, OZ279, OZ280, OZ281, OZ282, OZ283, OZ284, OZ285, OZ286, OZ287, OZ288, OZ289, OZ290, OZ291, OZ292, OZ293, OZ294, OZ295, OZ296, OZ297, OZ298, OZ299, OZ300, OZ301, OZ302, OZ303, OZ304, OZ305, OZ306, OZ307, OZ308, OZ309, OZ310, OZ311, OZ312, OZ313, OZ314, OZ315, OZ316, OZ317, OZ318, OZ319, OZ320, OZ321, OZ322, OZ323, OZ324, OZ325, OZ326, OZ327, OZ328, OZ329, OZ330, OZ331, OZ332, OZ333, OZ334, OZ335, OZ336, OZ337, OZ338, OZ339, OZ340, OZ341, OZ342, OZ343, OZ344, OZ345, OZ346, OZ347, OZ348, OZ349, OZ350, OZ351, OZ352, OZ353, OZ354, OZ355, OZ356, OZ357, OZ358, OZ359, OZ360, OZ361, OZ362, OZ363, OZ364, OZ365, OZ366, OZ367, OZ368 and OZ369.