A pharmaceutical composition having antiphlogistic-analgestic activity using an oral-micro emulsuion drug delivery system is provided, which composition improves medicinal efficacy expressing time and absorption of hardly soluble drugs, so that the dosage amount of the drugs can be reduced. The pharmaceutical composition having antiphlogistic-analgestic activity using an oral-micro emulsuion drug delivery system comprises 1 to 40 wt.% of antiphlogistic-analgestic active ingredients; 5 to 50 wt.% of surfactant, 10 to 50 wt.% of solubilizing agent; 10 to 50 wt.% of co-surfactant; 0.1 to 5 wt.% of pH regulating agent; and 1 to 5 wt.% of antioxidant, wherein the antiphlogistic-analgestic active ingredient is ibuprofen or dexibuprofen; the surfactant is castor oil, substituted castor oil, tween, span, laborasol and brij; the solubilizing atent is fatty acid ester, vegetable oil, purfied fish oil and pharmaceutically acceptable hydrophobic solubilizing agent; the co-surfactant is selected from glycofurol, polyethyleneglycol, propyleneglycol, dimethylisosorbide, diethyleneglycolmonoethylether, apricot kernel oil, propyleneglycolmonolaurate and tetraglycol; and the pH regulating agent is monoethanolamine, diethanolamine and triethanolamine.
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