A SIMULATION OF INTERSTITIAL CELLS OF CAJAL IN THE SMALL INTESTINE

摘要

Rhythmic contractions of the gastrointestinal tract, including the small intestine is associated with pacemaker activity that occurs in the muscle. This activity is occurring less frequently without outside stimulation. The pacemaker activities have been known to occur by the ICC (interstitial cells of Cajal) distributed in the gastrointestinal tract near the interlayer region. Pacemaker activity has spread to the muscle through the gap junction (gap junction) causes the contraction of the entire gastrointestinal tract. The invention can describe or predict the various changes, such as a slow wave characteristics that are repeated automatically by simulating the pacemaker activity by the ICC as part of the small intestine and the mathematical model of intracellular calcium. Pathogenesis of slow wave described in the present invention are as follows. Calcium influx into cells is to cause the incoming SR calcium release mediated by _{IP 3 (inositol 1,4,5-trisphosphate)} . Increase in cytosolic calcium induced by the influx of calcium into the mitochondria largely lowers the calcium concentration of the non-selective cation channel region. Activation of these passages will cause a pacemaker current. Pacemaker current depolarization of the cells and makjeonap, this depolarization will cause a change in the IP ₃ metabolism (inositol 1,4,5-trisphosphate) that increases the amount of zoom. Increase in IP ₃ is given continuous increase in the intracellular calcium calcium-dependent Cl ^- to activate a pathway, non-selective cation channel, and thus the cells maintain the plateau voltage. When the internal calcium gradually reduced by the calcium pump, cells should recover a stable membrane potential.