Mimetic peptides for epitope of apolipoprotein B-100, concatemer and modified peptides thereof, and the vaccine composition comprising the same

摘要

PURPOSE: Provided are mimetic peptides for epitope of apolipoprotein b-100, their concatemers and modified peptides, and a vaccine composition comprising them. The vaccine composition is used for the treatment of obesity. CONSTITUTION: The mimetic peptides for epitope of apolipoprotein B-100 are represented by the SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3. Their concatemers consist of 1-15, preferably 4 mimetic peptides. The vaccine composition for the treatment of obesity contains them and is formulated into an intradermal injection. Their manufacturing method comprises the steps of: inserting DNA coding mimetic peptides for epitope of apolipoprotein b-100, their concatemers and modified peptides, into a vector; transforming a strain with the vector then culturing it; and separating mimetic peptides for epitope of apolipoprotein b-100, their concatemers and modified peptides from the culture.