NEUTRALIZING EPITOPE FOR PORCINE EPIDEMIC DIARRHEA VIRUS AND USE THE SAME

摘要

PURPOSE: A neutralizing epitope for porcine epidemic diarrhea virus and the use thereof are provided, thereby effectively preventing and treating the infection of porcine epidemic diarrhea virus. CONSTITUTION: A neutralizing epitope for porcine epidemic diarrhea virus(PEDV) comprises a polypeptide of SEQ ID NO: 1, wherein X22 is Asp or Gly, X 23 is Ser or Leu, X24 is Ser or Gly, X25 is Ser or Gly, X51 is Thr or Arg, X58 is Asn or Ser, X114 is Leu or Phe, and X137 is Ile or Val. A gene encoding the neutralizing epitope for porcine epidemic diarrhea virus has the nucleotide sequence of SEQ ID NO: 2. An anti-serum to PEDV is produced by injecting the PEDV epitope to an animal and collecting the anti-serum to PEDV from the immunized animal. An antibody to PEDV is isolated from the anti-serum to PEDV. A vaccine composition comprises the PEDV epitope.