The method of preparing optically active 1,2-diol derivatives and their esters by enzymatic method

摘要

The present invention relates to a method of making a following [Scheme 1] in an optically active alcohol and its esters which are respectively represented by formulas 2 and 3 by the alcohol compound in enzymatic methods shown by the general formula [1]. More specifically, the lipase enzyme, using as a catalyst a pharmaceutical intermediates by ester reaction group one alcohol to stereoselectively using the alcohol compound represented by the general formula (1) only to the reaction in an organic solvent, or acyl donor (acyl donor) It relates to a process for producing the optically active alcohol and an ester frequently used. The process according to the invention with high optical purity by the 1,2-diol (1,2-diol) compound of the first (primary) with the rear lipase by converting an alcohol, a second (secondary) alcohol ester group reaction with Stereoselective it is possible to obtain a yield of the optically active alcohol and an ester.;