BETA-CATENIN OLIGONUCLEOTIDE MICROCHIP AND METHOD FOR DETECTING BETA-CATENIN MUTATIONS EMPLOYING SAME

摘要

The present invention is fixed to the surface of the solid substrate by oligonucleotide designed to search for the various mutants can be generated from the β- catenin (β-catenin) mutant concentration codon region (hot-spot areas) of the gene using an automated microarray of oligonucleotides was directed to a method of inspecting a mutation of β- catenin gene by method of β- catenin β- catenin oligonucleotide microchip, the microchip can search for mutations in the gene and using them. β- catenin oligonucleotide microchip of the present invention by devising an oligonucleotide concentration for a particular mutant codon region of the oligonucleotide existing common nucleotide chip unlike β- catenin gene optionally excellent accuracy and economy of β- catenin gene mutation research and cancer mechanism of signal transduction pathways related to the search and β- catenin gene may be useful in the study.