A method of predicting the development and course of chronic lymphocytic leukemia

摘要

method u043fu0440u043eu0433u043du043eu0437u0438u0440u043eu0432u0430u043du0438u00a0 u0440u0430u0437u0432u0438u0442u0438u00a0 and u0442u0435u0447u0435u043du0438u00a0 chronic u043bu0438u043cu0444u043eu043bu0435u0439u043au043eu0437u0430 by u0442u0438u043fu0438u0440u043eu0432u0430u043du0438u00a0 polymorphism dna from blood lymphocytes of a patient TNF - alfa and TNF genes - beta u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 because of the lymphocytes of peripheral venous blood, u0432u044bu0434u0435u043bu00a0u044eu0442 dna method u043fu043eu043bu0438u043cu0435u0440u0430u0437u043du043e chain reaction of synthesis of dna, u043fu0440u043eu0432u043eu0434u00a0u0442 u0433u0435u043du043eu0442u0438u043fu0438u0440u043eu0432u0430u043du0438u0435 poly u043cu043eu0440u0444u0438u0437u043cu0430 u043fu0440u043eu043cu043eu0442u043eu0440u043du044bu0445 areas genes TNF andand in the u0432u044bu00a0u0432u043bu0435u043du0438u0438 genotyping lt * 22, u0445u0430u0440u0430u043au0442u0435u0440u0438u0437u0443u044eu0449u0435u0433u043eu0441u00a0 of gene mutation TNF - u0433u043eu043cu043eu0437u0438u0433u043eu0442u043du043eu043c u0441u043eu0441u0442u043eu00a0u043du0438u0438, u0432u044bu00a0u0432u043bu00a0u044eu0442 individuals prone to develop chronic u043bu0438u043cu0444u043e leukemia, and in identifying the combinations of genotypes TNF * 22 * 22 / lt and TNF * 12 / lt * 11 in patients with chronic u043bu0438u043cu0444u043eu043bu0435u0439u043au043eu0437u043eu043c an aggressive course of u0437u0430u0431u043eu043bu0435u0432u0430u043du0438u00a0.