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METHOD FOR DETECTING FUNCTIONAL ACTIVITY OF CYTOKINS THAT SUPPRESS T-LYMPHOCYTES IN NEONATALS
METHOD FOR DETECTING FUNCTIONAL ACTIVITY OF CYTOKINS THAT SUPPRESS T-LYMPHOCYTES IN NEONATALS
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机译:检测抑制新生儿T淋巴细胞的细胞因子功能活性的方法
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摘要
FIELD: medicine, immunology.;SUBSTANCE: one should carry out reaction of blast-transformation, detect proliferation of T-lymphocytes activated with antibodies to CD3 in the presence of interleukin-7 (ACT IL-7) and in the presence of interleukin-7 and dexametazone (ACT IL-7 D), calculate the index for dexametazone action as the ratio of ACT IL-7 to ACT IL-7 D, moreover, the value of dexametazone action index being above 1.2 indicates increased production of cytokins that suppress T-lymphocytes in neonatals. The method enables to detect functional defect of immune system that characterizes neonatal period.;EFFECT: higher efficiency of detection.;2 ex
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机译:领域:医学,免疫学;研究方向:应该进行白细胞转化反应,在存在白介素7(ACT IL-7)和存在白介素7的情况下,检测被CD3抗体激活的T淋巴细胞的增殖。 7和地塞米松(ACT IL-7 D),以ACT IL-7与ACT IL-7 D的比值计算地塞米松作用的指数,此外,地塞米松作用指数的值大于1.2表示抑制细胞因子的产生增加新生儿中的T淋巴细胞。该方法能够检测表征新生儿时期的免疫系统功能缺陷。效果:更高的检测效率。2 ex
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