AGENT ELICITING ANTICOAGULATING AND IMMUNOTROPIC EFFECT

摘要

FIELD: chemistry of natural compounds, medicine.;SUBSTANCE: invention relates to the development of anticoagulant of vegetable origin. Agent eliciting anti-coagulating and immunotropic effect represents fucoidan prepared from brown alga Fucus evanescens by extraction with water at temperature 20-60^oC followed by precipitation with ethanol. Fucoidan has molecular mass 20000-40000 Da and contains the following neutral monosaccharides, %: fucose, 70-80; galactose, 2-9; xylose, 5-10, and glucose, 2-7, and also sulfates, 20-22%. Fucoidan shows intensive signals in [¹³C]-NMR spectrum at 16.0-18.0 m.d. and the absorption band in IR-spectrum at 820-822 cm^-1. Fucoidan stimulates phagocyte and bactericidal activity of neutrophiles being in the large and small doses and elicits immunostimulating effect in the broad range of doses.;EFFECT: valuable medicinal properties of agent.;2 dwg, 3 tbl