S-SUBSTITUTED (HETERO)ARYLALKYLISOTHIOUREAS, PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION, INVESTIGATION OF GLUTAMATERGIC SYSTEM, TREATMENT METHODS (VARIANTS)

摘要

FIELD: organic chemistry, pharmaceutical industry, medicine.;SUBSTANCE: invention relates to new derivatives of S-substituted N-1-[(hetero)aryl]alkyl-N'-1-[(hetero)aryl]alkylisothioureas of general formula I; ;in form of free base and salts with pharmaceutically accepted acids, as well as racemate, individual optical isomers or mixture thereof. In formula R¹, R², R³, R⁴, Y and Z are as described in specification. Compounds of present invention are capable to potentiate (positively modulate) AMPA/KA glutamate receptors and simultaneously to block transmembrane currents induced by activation of NMDA glutamate receptors. Also disclosed are method for production of said compounds, including optical isomers; pharmaceutical composition; method for investigation of glutamatergic system, and method for Alzheimer's disease, treatment; as well as method for extreme retentiveness of memory by administering of effective amount of claimed compounds.;EFFECT: new pharmaceutically active compounds for Alzheimer's disease treatment.;23 cl, 1 tbl, 11 ex