FIELD: medicine, pharmacy.;SUBSTANCE: invention proposes applying oltipraz, i. e. 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione, known early as agent used against schistosomiasis and carcinogenesis for prophylaxis and treatment of liver progressing fibrosis and cirrhosis and for manufacturing a medicinal drug of indicated designation. Also, invention relates to pharmaceutical composition containing oltipraz and a method for its using. Oltipraz exhibits effect on liver and provides protecting effect against hepatotoxicity due to inhibition of producing -TGF.;EFFECT: valuable medicinal properties of oltipraz and pharmaceutical composition.;6 cl, 4 dwg, 14 ex
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机译：领域：药物，药学;实质：发明提出应用oltipraz，即。 e。 5-（2-吡嗪基）-4-甲基-1,2-二硫基-3-硫酮，早期被称为抗血吸虫病和致癌作用的试剂，用于预防和治疗肝脏进行性纤维化和肝硬化，以及用于制造指定用途的药物。另外，本发明涉及一种含有oltipraz的药物组合物及其使用方法。 Oltipraz通过抑制-TGF的产生对肝脏表现出作用并提供抗肝毒性的保护作用。;作用：Oltipraz的有价值的药物特性和药物组合物; 6 cl，4 dwg，14 ex
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