Optically active heteroaromatic β-hydroxy esters and processes for their preparation and their use as intermediates in the epothilone total synthesis

摘要

The present invention describes optically active heteroaromatic beta-hydroxy esters and processes for their preparation from beta-keto esters and to processes for preparing these beta-keto esters. DOLLAR A The present invention makes it possible to obtain from a literature known starting material in a very short sequence (two stages) to the heteroaromatic beta-hydroxy esters in high overall yield and high optical purity.