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identification of ligands for orphan receptors using mass spectrometry
identification of ligands for orphan receptors using mass spectrometry
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机译:质谱鉴定孤儿受体配体
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摘要
The present invention relates to the on-line coupling of mass spectrometry (MS) to continuous-flow separation techniques for detecting 'orphan' analytes, viz. receptors which do not have known ligands. In a further embodiment, this on-line detection method is used as either a screening method for assays with an unknown ligand. Furthermore, this invention relates to compounds detected by this method and the use of these compounds as a ligand for affinity molecules.
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