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A method for the preparation of formulations for the direct tabletting
A method for the preparation of formulations for the direct tabletting
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机译:一种直接压片制剂的制备方法
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摘要
A thermal adhesion granulation process for preparing direct tabletting formulations or aids is disclosed. The process comprises the step of subjecting all or part of a mixture comprising: ;A) from about 5 to about 99% by weight of one or more diluent excipients and/or from 0 to about 99% by weight of a pharmaceutically active ingredient; ;B) from about 1 to about 95% by weight of a binder excipient; optionally with, ;C) from 0 to about 10% by weight of a disintegrant excipient; ;to heating at a temperature in the range of from about 30 to about 130° C under the condition of low moisture or low content of a pharmaceutically-acceptable organic solvent in a closed system under mixing by tumble rotation until the formation of granules.
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