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wet granulationsverfahren for the manufacture of pharmaceutical tablets with paroxetinhydrochlorid anhydrat
wet granulationsverfahren for the manufacture of pharmaceutical tablets with paroxetinhydrochlorid anhydrat
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机译:湿法制粒verfahren,用于生产盐酸帕罗西汀无水药片
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摘要
Pharmaceutical tablets containing crystalline paroxetine hydrochloride anhydrate are prepared using a process comprising an initial wet granulation process in which an aqueous granulation liquid is added to a mixture of said anhydrate an excipients under high-shear conditions and the thus obtained wet granules are dried using a fluidized bed technique to obtain a water activity within a specified range, after which the dried granules after addition of further adjuvants are compressed into stable tablets each having an identical composition.
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