首页> 外国专利> New aralkyl tetrahydropyridines useful as alpha tumor necrosis factor modulators, for the treatment of e.g. immunitory and inflammatory disorders, pain, Alzheimer's, Parkinson's, HIV and cancer

New aralkyl tetrahydropyridines useful as alpha tumor necrosis factor modulators, for the treatment of e.g. immunitory and inflammatory disorders, pain, Alzheimer's, Parkinson's, HIV and cancer

机译:可用作α肿瘤坏死因子调节剂的新的芳烷基四氢吡啶,用于治疗例如α-氨基丁酸。免疫和炎性疾病,疼痛,老年痴呆症,帕金森氏症,艾滋病毒和癌症

摘要

The present invention relates to compounds of formula (I): in which X represents N or CH; RSUB1 /SUBrepresents a hydrogen or halogen atom or a CFSUB3 /SUBgroup; n is an integer from 1 to 5; A represents a partially saturated carbonaceous bi- or tricycle; it also relates to their salts, solvates, N-oxides, the pharmaceutical compositions containing them, a method for their preparation and synthesis intermediates in this method.
机译:本发明涉及式(I)的化合物:其中X代表N或CH;和R 1 代表氢或卤素原子或CF 3 基团; n为1至5的整数; A代表部分饱和的碳双环或三环;它还涉及它们的盐,溶剂化物,N-氧化物,包含它们的药物组合物,其制备方法和该方法中的合成中间体。

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