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NEW POLYMERIC COMPLEXES FOR TRANSFECTION OF NUCLEAR CLAUSES, WITH RESIDUES FOR DESTABILIZATION OF CELL MEMBRANES
NEW POLYMERIC COMPLEXES FOR TRANSFECTION OF NUCLEAR CLAUSES, WITH RESIDUES FOR DESTABILIZATION OF CELL MEMBRANES
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机译:用于穿透核子句的新的聚合物配合物,以及用于破坏细胞膜的残基
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摘要
The complex has at least one negatively charged nucleic acid bonded to at least one positively charged polymeric conjugateThe conjugate containing a polylysine formed from monomers having free NH3+ groups, and having at least 10% of the free NH3+ groups substituted by residues which can be protonated in a weakly acid medium causing destabilization of cell membranes.Optionally, some of the free NH3+ groups can be substituted by a molecule with a recognition signal by a cell membrane receptor.The free NH3+ groups of the said polylysine make up at least 30% of the monomers of the polymeric conjugate.The residue that causes the destabilization of cell membrane in weak acid of quinolines of the formula:where R1 is hydrogen, R2 is -(CH2)n13 CO2-H, X is hydrogen or chlorine and n is an integer from 1 to 10.The signal is a simple oside or a disaccharide or peptide.
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