首页>
外国专利>
antibodies against the b domain of fibronektin conjugates containing such antibodies, and their use for the diagnosis and therapy of tumors and diseases associated with angiogenesis.
antibodies against the b domain of fibronektin conjugates containing such antibodies, and their use for the diagnosis and therapy of tumors and diseases associated with angiogenesis.
The present invention relates to antibodies with sub-nanomolar affinity specific for a characteristic epitope of the ED-B domain of fibronectin, a marker of angiogenesis Furthermore, it relates to the use of radiolabeled high affinity anti ED-B antibodies for detecting new-forming blood vessels in vivo and a diagnostic kit comprising comprising said antibody. Furthermore, it relates to conjugates comprising said antibodies and a suitable photoactive molecules (e.g. a judiciously chosen photosensitizer), and their use for the selective light-mediated occlusion of new blood vessels.
展开▼