COMPOUND, COMPOSITION AND METHOD FOR PREVENTING NERVE DEGENERATION RESULTING FROM ACUTE AND CHRONIC INJURY IN CENTRAL NERVOUS SYSTEM

摘要

PROBLEM TO BE SOLVED: To provide a composition and a method for preventing neurological diseases accompanying death of neuron.;SOLUTION: A 5-benzylaminosalicylic acid (BAS) and its derivative protect cerebrocortical neurons from toxic injury due to an N-methyl-D-aspartate, Zn²⁺ and reactive enzymes. Thereby, the composition and the method for treating serious seizure accompanied by loss of neuron, traumatic brain injury, traumatic spinal damage, epilepsy and neurodegenerative disease, due to excitotoxicity, Zn²⁺ neurotoxicity and free radical neurotoxicity.;COPYRIGHT: (C)2006,JPO&NCIPI