INDUCTION OF REV AND TAT SPECIFIC CYTOTOXIC T-CELLS FOR PREVENTION AND TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION

摘要

PPROBLEM TO BE SOLVED: To provide a method and composition (including immunologic composition such as vaccine) targeting prevention and treatment of AIDS. PSOLUTION: The presence of cytotoxic T-cells to the Rev and/or Tat protein in samples from a subject infected with immunodeficiency virus, particularly HIV in humans, is an indication of a stable disease condition and a favorable prognosis of lack of progression of disease. Immunogenic compositions containing at least one cytotoxic T-cell epitope of the Rev and/or Tat protein of an immunodeficiency virus, particularly HIV, or a vector encoding the T-cell epitope, may be used to prevent infection by disease caused by the immunodeficiency virus, by inducing, in the host, a specific cytotoxic T-cell response specific for the respective Rev and/or Tat proteins. PCOPYRIGHT: (C)2007,JPO&INPIT