Antiviral agent 1S- (1α, 3α, 4β)-2-amino-1,9-dihydro-9- 4-hydroxy-3- (hydroxymethyl) -2-methylenecyclopentyl -6H-purine-6 -Manufacturing method of ON

摘要

The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophobic resin bed; (b) washing the resin bed with water to remove sa and (c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.