Method for differentiating mesenchymal stem cells into hepatocytes and artificial human hepatocytes

摘要

Since hepatocytes are difficult to establish, mesenchymal stem cells that have been established for proliferation, especially stromal cells that are bone marrow-derived mesenchymal stem cells, are differentiated into hepatocytes, resulting in liver damage. It is an object of the present invention to provide a means for preparing hepatocytes useful for cell transplantation therapy. Capable of differentiating human mesenchymal stem cells into hepatocytes and mature hepatocytes by transplanting human mesenchymal stem cells into the liver of a mammal that has suffered chronic liver damage, such as rats, by continuing drug administration And developed a means to differentiate mesenchymal stem cells into mature hepatocytes.