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I. A. 4- (3,5-dicyanophenoxy) pyrazole derivatives for use as reverse transcriptase modulators in the treatment of HIV
I. A. 4- (3,5-dicyanophenoxy) pyrazole derivatives for use as reverse transcriptase modulators in the treatment of HIV
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机译:I.A. 4-(3,5-二氰基苯氧基)吡唑衍生物用作HIV逆转录酶调节剂
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摘要
This invention relates to the pyrazole derivatives of formula (I) and pharmaceutically acceptable salt, solvate or derivatives thereof, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. The compounds of the invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors, thereof. Reverse transcriptase is implicated in the infectious lifecycle of Human Immunodeficiency Virus (HIV). Compounds which interfere with the function of this enzyme have shown utility in the treatment of conditions caused by HIV and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).
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