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Myostatin metalloprotease activation and method of modulating myostatin activity
Myostatin metalloprotease activation and method of modulating myostatin activity
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机译:肌生成抑制素金属蛋白酶激活和调节肌生成抑制素活性的方法
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摘要
The invention provides an in vitro method of decreasing myostatin activation. The method comprises contacting a sample comprising a latent myostatin complex comprising a myostatin pro peptide and a myostatin C-terminal fragment, and a metalloprotease that can cleave the myostatin pro peptide, with an agent that decreases proteolytic cleavage of the pro peptide by the metalloprotease, thereby decreasing myostatin activation. The metalloprotease is a bone morphogenic protein-1/tolloid (BMP-1/TLD) family member and the agent is a peptide selected from the group consisting of SEQ ID NOS: 9-23. Also provided is such an agent for use in decreasing myostatin activation in a subj ect.
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机译:本发明提供了降低肌生长抑制素活化的体外方法。该方法包括使包含潜在的肌肉生长抑制素复合物的样品与减少金属肽水解酶原肽的蛋白水解的试剂接触,所述潜在的肌肉生长抑制素复合物包含肌生长抑制素原肽和肌生长抑制素C-末端片段,所述金属蛋白酶可以切割肌生长抑制素原肽。从而减少肌生长抑制素的活化。金属蛋白酶是骨形态发生蛋白-1 / tolloid(BMP-1 / TLD)家族成员,并且该试剂是选自SEQ ID NOS:9-23的肽。还提供了用于减少受试者体内肌肉生长抑制素活化的试剂。
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