Activation control method of transcription factors NF-AT, AP-1 and NF-κB utilizing the activation action of adapter protein 3BP2

摘要

The transcription factor activation control method of the present invention controls the activity of intracellular transcription factors NF-AT, AP-1 and NF-κB by controlling the expression level of adapter protein 3BP2 or by expressing the mutant protein. This is a method of selective control. According to the method of the present invention, when controlling the activity of a specific transcription factor, a desired method is selected from a plurality of activity control methods according to the purpose in relation to the activation of other transcription factors. Can do. Further, the present invention can be used for the development of therapeutic methods and therapeutic agents for various diseases such as inflammatory diseases, immune diseases, and malignant diseases.