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New synthetic intermediate field and its production method of karubapenemu chemical compound for oral administration
New synthetic intermediate field and its production method of karubapenemu chemical compound for oral administration
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机译:氨基甲酸酯类化合物的合成新中间体领域及其生产方法
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摘要
This invention offers the new synthetic intermediate field and its production method in order to produce the 1- mechirukarubapenemu chemical compound for oral administration efficiently. In other words, this invention is displayed with general system it is production method of the new - lactam compound which (3) the new - lactam compound which (1) makes the new - lactam compound which (6) reacts under existing of chemical compound and the base which (5) designates the - lactam compound which as the starting raw materials, are displayed with general system is displayed with, general system after protecting hydroxyl group, is displayed with general system profit, features that this is protected deviation from the cyclization point strongly under existing of the base, furthermore by reacting with chloridation diphenyl phosphoric acid, is displayed with general system (4).(In formula, R1: torimechirushiriru basis or toriechirushiriru basis, R2: Aryl basis or hetero aryl basis, R3: Carbon count alkyl group or carbon count shikuroarukiru 3 of 1 - 10 - 10, X: The halogen atom is shown)
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