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Low cost fabrication of microelectrode arrays for cell-based biosensors and drug discovery methods
Low cost fabrication of microelectrode arrays for cell-based biosensors and drug discovery methods
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机译:用于基于细胞的生物传感器的微电极阵列的低成本制造和药物发现方法
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摘要
A method for making a plurality of low-cost microelectrode arrays (MEAs) on one substrate utilizing certain unmodified printed circuit board (PCB) fabrication processes and selected materials. In some embodiments, a MEA device is composed of a thin polymer substrate containing patterned conductive traces. Coverlays on both sides of the substrate insulate the conductive traces and defines the electrodes. Preferably, flexible PCB technology is utilized to simultaneously define the microelectrode arrays. In an embodiment, the sensor is an integrated temperature sensor/heater in which the MEA device operates to record extracellular electrical signals from electrically active cell cultures. The present invention enables economical and efficient mass production of MEA devices, making them particularly suitable for disposable applications such as drug discovery, biosensors, etc.
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