Peptides capable of inducing attraction to the axonal growth and their use for treating neurodegenerative diseases

摘要

The present invention is directed to peptides comprising the sequence ASNKL (SEQ ID No. 1), inducing attraction of the axonal growth in presence of the semaphorin (Sema3A), L1 and NP-1 proteins and their use for the manufacture of a drug for neuronal/axonal regeneration or for treating neurodegenerative diseases. The present invention also includes a method for identifying a compound able to bind the NP-1, a method for identifying a compound able to revert the repulsory effect of Sema3A on the axonal growth from a suited cell, or methods to screen for molecules capable of blocking Sema3A-induced endocytosis.