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Combination therapy of an SODm and a corticosteroid for prevention and/or treatment of inflammatory bone or joint disease
Combination therapy of an SODm and a corticosteroid for prevention and/or treatment of inflammatory bone or joint disease
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机译:SODm和皮质类固醇的联合疗法可预防和/或治疗炎症性骨或关节疾病
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摘要
The present invention relates to pharmaceutical compositions and methods of using such compositions for the treatment of inflammatory diseases of the bone and joints. The compositions comprise a catalyst for the dismutation of superoxide, which is a non-proteinaceous mimetic of superoxide dismutase, in combination with a corticosteroid. The combination is substantially more effective than either the superoxide dismutase mimetic or the corticosteroid given alone at the same dose. Treatment with the combination beneficially alters the progression of the inflammatory bone and joint disease as measured histologically in diminished bone resorption and infiltration of inflammatory cells; as measured radiographically in diminished joint erosion, and diminished bone erosion and osteophyte formation; and as measured histomorphometrically in decreased bone resorption measurements of eroded surface and/or osteoclast surface relative to bone surface, and increased bone formation measurements of osteoblast surface relative to bone surface.
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